IDENTIFICATION AND CHARACTERIZATION OF 22 GENES THAT AFFECT THE VULVAL CELL LINEAGES OF THE NEMATODE CAENORHABDITIS ELEGANS

Edwin L. Ferguson 1 and H. Robert Horvitz 1

1 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Ninety-five mutants of the nematode Caenorhabditis elegans altered in the cell lineages of the vulva have been isolated on the basis of their displaying one of two phenotypes, Vulvaless or Multivulva. In Vulvaless mutants, which define 12 genes, no vulva is present. In Multivulva mutants, which define ten genes, one or more supernumerary vulva-like protrusions are located along the ventral side of the animal. A single recessive mutation is responsible for the phenotypes of most, but not all, of these strains. Fifteen of these 22 genes are represented by multiple alleles. We have shown by a variety of genetic criteria that mutations that result in a Vulvaless or Multivulva phenotype in six of the 22 genes most likely eliminate gene function. In addition, Vulvaless or Multivulva mutations in seven of the other genes most likely result in a partial reduction of gene function; the absence of the activity of any of these genes probably results in lethality or sterility. Our results suggest that we may have identified most, or all, genes of these two classes.

Submitted on October 29, 1984
Accepted on January 18, 1985




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
X. Yang, J. Zou, D. R. Hyde, L. A. Davidson, and X. Wei
Stepwise Maturation of Apicobasal Polarity of the Neuroepithelium Is Essential for Vertebrate Neurulation
J. Neurosci., September 16, 2009; 29(37): 11426 - 11440.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
G.-d. Zhu, G. Salazar, S. A. Zlatic, B. Fiza, M. M. Doucette, C. J. Heilman, A. I. Levey, V. Faundez, and S. W. L'Hernault
SPE-39 Family Proteins Interact with the HOPS Complex and Function in Lysosomal Delivery
Mol. Biol. Cell, February 1, 2009; 20(4): 1223 - 1240.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. Milloz, F. Duveau, I. Nuez, and M.-A. Felix
Intraspecific evolution of the intercellular signaling network underlying a robust developmental system
Genes & Dev., November 1, 2008; 22(21): 3064 - 3075.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
E. C. Andersen, A. M. Saffer, and H. R. Horvitz
Multiple Levels of Redundant Processes Inhibit Caenorhabditis elegans Vulval Cell Fates
Genetics, August 1, 2008; 179(4): 2001 - 2012.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
B. D. Galvin, S. Kim, and H. R. Horvitz
Caenorhabditis elegans Genes Required for the Engulfment of Apoptotic Corpses Function in the Cytotoxic Cell Deaths Induced by Mutations in lin-24 and lin-33
Genetics, May 1, 2008; 179(1): 403 - 417.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. L. Green, T. Inoue, and P. W. Sternberg
The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway
Development, November 15, 2007; 134(22): 4053 - 4062.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Modzelewska, M. G. Elgort, J. Huang, G. Jongeward, A. Lauritzen, C. H. Yoon, P. W. Sternberg, and N. Moghal
An Activating Mutation in sos-1 Identifies Its Dbl Domain as a Critical Inhibitor of the Epidermal Growth Factor Receptor Pathway during Caenorhabditis elegans Vulval Development
Mol. Cell. Biol., May 15, 2007; 27(10): 3695 - 3707.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
M. M. Harrison, X. Lu, and H. R. Horvitz
LIN-61, One of Two Caenorhabditis elegans Malignant-Brain-Tumor-Repeat-Containing Proteins, Acts With the DRM and NuRD-Like Protein Complexes in Vulval Development but Not in Certain Other Biological Processes
Genetics, May 1, 2007; 176(1): 255 - 271.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
Y. Matsubara, I. Kawasaki, S. Urushiyama, T. Yasuda, M. Shirakata, Y. Iino, H. Shibuya, and Y. Yamanashi
The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans
Genes Cells, March 1, 2007; 12(3): 407 - 420.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
B. P. Gupta, J. Liu, B. J. Hwang, N. Moghal, and P. W. Sternberg
sli-3 Negatively Regulates the LET-23/Epidermal Growth Factor Receptor-Mediated Vulval Induction Pathway in Caenorhabditis elegans
Genetics, November 1, 2006; 174(3): 1315 - 1326.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. C. Andersen, X. Lu, and H. R. Horvitz
C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates
Development, July 15, 2006; 133(14): 2695 - 2704.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
C. J. Ceol, F. Stegmeier, M. M. Harrison, and H. R. Horvitz
Identification and Classification of Genes That Act Antagonistically to let-60 Ras Signaling in Caenorhabditis elegans Vulval Development
Genetics, June 1, 2006; 173(2): 709 - 726.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
P. W. Sternberg
Pathway to RAS.
Genetics, February 1, 2006; 172(2): 727 - 731.
[Full Text] [PDF]

Home page
 GeneticsHome page
M. A. Chesney, A. R. Kidd III, and J. Kimble
gon-14 Functions With Class B and Class C Synthetic Multivulva Genes to Control Larval Growth in Caenorhabditis elegans
Genetics, February 1, 2006; 172(2): 915 - 928.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
E. J. Gleason, W. C. Lindsey, T. L. Kroft, A. W. Singson, and S. W. L'Hernault
spe-10 Encodes a DHHC-CRD Zinc-Finger Membrane Protein Required for Endoplasmic Reticulum/Golgi Membrane Morphogenesis During Caenorhabditis elegans Spermatogenesis
Genetics, January 1, 2006; 172(1): 145 - 158.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
I. Katic, L. G. Vallier, and I. Greenwald
New Positive Regulators of lin-12 Activity in Caenorhabditis elegans Include the BRE-5/Brainiac Glycosphingolipid Biosynthesis Enzyme
Genetics, December 1, 2005; 171(4): 1605 - 1615.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
D. J. Eastburn and M. Han
A Gain-of-Function Allele of cbp-1, the Caenorhabditis elegans Ortholog of the Mammalian CBP/p300 Gene, Causes an Increase in Histone Acetyltransferase Activity and Antagonism of Activated Ras
Mol. Cell. Biol., November 1, 2005; 25(21): 9427 - 9434.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. C. Fleming, F. W. Wolf, and G. Garriga
Sensitized genetic backgrounds reveal a role for C. elegans FGF EGL-17 as a repellent for migrating CAN neurons
Development, November 1, 2005; 132(21): 4857 - 4867.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
E. M. Davison, M. M. Harrison, A. J. M. Walhout, M. Vidal, and H. R. Horvitz
lin-8, Which Antagonizes Caenorhabditis elegans Ras-Mediated Vulval Induction, Encodes a Novel Nuclear Protein That Interacts With the LIN-35 Rb Protein
Genetics, November 1, 2005; 171(3): 1017 - 1031.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. Maciejowski, J. H. Ahn, P. G. Cipriani, D. J. Killian, A. L. Chaudhary, J. I. Lee, R. Voutev, R. C. Johnsen, D. L. Baillie, K. C. Gunsalus, et al.
Autosomal Genes of Autosomal/X-Linked Duplicated Gene Pairs and Germ-Line Proliferation in Caenorhabditis elegans
Genetics, April 1, 2005; 169(4): 1997 - 2011.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Dalpe, L. Brown, and J. G. Culotti
Vulva morphogenesis involves attraction of plexin 1-expressing primordial vulva cells to semaphorin 1a sequentially expressed at the vulva midline
Development, March 15, 2005; 132(6): 1387 - 1400.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
L. Broday, I. Kolotuev, C. Didier, A. Bhoumik, B. P. Gupta, P. W. Sternberg, B. Podbilewicz, and Z. Ronai
The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans
Genes & Dev., October 1, 2004; 18(19): 2380 - 2391.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
G. R. Miley, D. Fantz, D. Glossip, X. Lu, R. M. Saito, R. E. Palmer, T. Inoue, S. van den Heuvel, P. W. Sternberg, and K. Kornfeld
Identification of Residues of the Caenorhabditis elegans LIN-1 ETS Domain That Are Necessary for DNA Binding and Regulation of Vulval Cell Fates
Genetics, August 1, 2004; 167(4): 1697 - 1709.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
X. Yin, N. J.D. Gower, H. A. Baylis, and K. Strange
Inositol 1,4,5-Trisphosphate Signaling Regulates Rhythmic Contractile Activity of Myoepithelial Sheath Cells in Caenorhabditis elegans
Mol. Biol. Cell, August 1, 2004; 15(8): 3938 - 3949.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
P. Joshi and D. M. Eisenmann
The Caenorhabditis elegans pvl-5 Gene Protects Hypodermal Cells From ced-3-Dependent, ced-4-Independent Cell Death
Genetics, June 1, 2004; 167(2): 673 - 685.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. J. Hwang and P. W. Sternberg
A cell-specific enhancer that specifies lin-3 expression in the C. elegans anchor cell for vulval development
Development, January 1, 2004; 131(1): 143 - 151.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Yu, R. F. Pretot, T. R. Burglin, and P. W. Sternberg
Distinct roles of transcription factors EGL-46 and DAF-19 in specifying the functionality of a polycystin-expressing sensory neuron necessary for C. elegans male vulva location behavior
Development, November 1, 2003; 130(21): 5217 - 5227.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
D. L. Church and E. J. Lambie
The Promotion of Gonadal Cell Divisions by the Caenorhabditis elegans TRPM Cation Channel GON-2 Is Antagonized by GEM-4 Copine
Genetics, October 1, 2003; 165(2): 563 - 574.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Moghal, L. R. Garcia, L. A. Khan, K. Iwasaki, and P. W. Sternberg
Modulation of EGF receptor-mediated vulva development by the heterotrimeric G-protein G{alpha}q and excitable cells in C. elegans
Development, October 1, 2003; 130(19): 4553 - 4566.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
G.-d. Zhu and S. W. L'Hernault
The Caenorhabditis elegans spe-39 Gene Is Required for Intracellular Membrane Reorganization During Spermatogenesis
Genetics, September 1, 2003; 165(1): 145 - 157.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. P. Gupta, M. Wang, and P. W. Sternberg
The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development
Development, June 15, 2003; 130(12): 2589 - 2601.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. H. Thomas, C. J. Ceol, H. T. Schwartz, and H. R. Horvitz
New Genes That Interact With lin-35 Rb to Negatively Regulate the let-60 ras Pathway in Caenorhabditis elegans
Genetics, May 1, 2003; 164(1): 135 - 151.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Moghal and P. W. Sternberg
A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans
Development, January 1, 2003; 130(1): 57 - 69.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H.-Y. Hwang and H. R. Horvitz
The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development
PNAS, October 29, 2002; 99(22): 14218 - 14223.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H.-Y. Hwang and H. R. Horvitz
The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated
PNAS, October 29, 2002; 99(22): 14224 - 14229.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
Y. K. Bui and P. W. Sternberg
Caenorhabditis elegans Inositol 5-Phosphatase Homolog Negatively Regulates Inositol 1,4,5-Triphosphate Signaling in Ovulation
Mol. Biol. Cell, May 1, 2002; 13(5): 1641 - 1651.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. M. Simon and P. W. Sternberg
Evidence of a mate-finding cue in the hermaphrodite nematode Caenorhabditis elegans
PNAS, January 24, 2002; (2002) 32225799.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Boxem and S. van den Heuvel
lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegans
Development, November 1, 2001; 128(21): 4349 - 4359.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. R. Sarafi-Reinach, T. Melkman, O. Hobert, and P. Sengupta
The lin-11 LIM homeobox gene specifies olfactory and chemosensory neuron fates in C. elegans
Development, September 1, 2001; 128(17): 3269 - 3281.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
M.-L. Dichtel, S. Louvet-Vallée, M. E. Viney, M.-A. Félix, and P. W. Sternberg
Control of Vulval Cell Division Number in the Nematode Oscheius/Dolichorhabditis sp. CEW1
Genetics, January 1, 2001; 157(1): 183 - 197.
[Abstract] [Full Text]

Home page
 GeneticsHome page
L. M. Miller, H. A. Hess, D. B. Doroquez, and N. M. Andrews
Null Mutations in the lin-31 Gene Indicate Two Functions During Caenorhabditis elegans Vulval Development
Genetics, December 1, 2000; 156(4): 1595 - 1602.
[Abstract] [Full Text]

Home page
 GeneticsHome page
L. Nilsson, T. Tiensuu, and S. Tuck
Caenorhabditis elegans lin-25: A Study of Its Role in Multiple Cell Fate Specification Events Involving Ras and the Identification and Characterization of Evolutionarily Conserved Domains
Genetics, November 1, 2000; 156(3): 1083 - 1096.
[Abstract] [Full Text]

Home page
 GeneticsHome page
D. M. Eisenmann and S. K. Kim
Protruding Vulva Mutants Identify Novel Loci and Wnt Signaling Factors That Function During Caenorhabditis elegans Vulva Development
Genetics, November 1, 2000; 156(3): 1097 - 1116.
[Abstract] [Full Text]

Home page
 Mol. Biol. CellHome page
C. H. Yoon, C. Chang, N. A. Hopper, G. M. Lesa, and P. W. Sternberg
Requirements of Multiple Domains of SLI-1, a Caenorhabditis elegans Homologue of c-Cbl, and an Inhibitory Tyrosine in LET-23 in Regulating Vulval Differentiation
Mol. Biol. Cell, November 1, 2000; 11(11): 4019 - 4031.
[Abstract] [Full Text]

Home page
 GeneticsHome page
A. Meléndez and I. Greenwald
Caenorhabditis elegans lin-13, a Member of the LIN-35 Rb Class of Genes Involved in Vulval Development, Encodes a Protein With Zinc Fingers and an LXCXE Motif
Genetics, July 1, 2000; 155(3): 1127 - 1137.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
D. Fay and M Han
Mutations in cye-1, a Caenorhabditis elegans cyclin E homolog, reveal coordination between cell-cycle control and vulval development
Development, January 9, 2000; 127(18): 4049 - 4060.
[Abstract] [PDF]

Home page
 Mol. Biol. CellHome page
B. Grant and D. Hirsh
Receptor-mediated Endocytosis in the Caenorhabditis elegans Oocyte
Mol. Biol. Cell, December 1, 1999; 10(12): 4311 - 4326.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
J. Hsieh, J. Liu, S. A. Kostas, C. Chang, P. W. Sternberg, and A. Fire
The RING finger/B-Box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans
Genes & Dev., November 15, 1999; 13(22): 2958 - 2970.
[Abstract] [Full Text]

Home page
 GeneticsHome page
J. M. Bosher, P. Dufourcq, S. Sookhareea, and M. Labouesse
RNA Interference Can Target Pre-mRNA: Consequences for Gene Expression in a Caenorhabditis elegans Operon
Genetics, November 1, 1999; 153(3): 1245 - 1256.
[Abstract] [Full Text]

Home page
 GeneticsHome page
J. Liu, P. Tzou, R. J. Hill, and P. W. Sternberg
Structural Requirements for the Tissue-Specific and Tissue-General Functions of the Caenorhabditis elegans Epidermal Growth Factor LIN-3
Genetics, November 1, 1999; 153(3): 1257 - 1269.
[Abstract] [Full Text]

Home page
 GeneticsHome page
A. G. Davies, C. A. Spike, J. E. Shaw, and R. K. Herman
Functional Overlap Between the mec-8 Gene and Five sym Genes in Caenorhabditis elegans
Genetics, September 1, 1999; 153(1): 117 - 134.
[Abstract] [Full Text]

Home page
 Mol. Biol. CellHome page
C. W. Whitfield, C. Bénard, T. Barnes, S. Hekimi, and S. K. Kim
Basolateral Localization of the Caenorhabditis elegans Epidermal Growth Factor Receptor in Epithelial Cells by the PDZ Protein LIN-10
Mol. Biol. Cell, June 1, 1999; 10(6): 2087 - 2100.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
L. I. Jiang and P. W. Sternberg
An HMG1-like protein facilitates Wnt signaling in Caenorhabditis elegans
Genes & Dev., April 1, 1999; 13(7): 877 - 889.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
P. D. Baum, C. Guenther, C. A. Frank, B. V. Pham, and G. Garriga
The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of the HSN motor neuron
Genes & Dev., February 15, 1999; 13(4): 472 - 483.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
A. Newman, G. Acton, E Hartwieg, H. Horvitz, and P. Sternberg
The lin-11 LIM domain transcription factor is necessary for morphogenesis of C. elegans uterine cells
Development, January 12, 1999; 126(23): 5319 - 5326.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J. Thomas and H. Horvitz
The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway
Development, January 8, 1999; 126(15): 3449 - 3459.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J Yochem, S Tuck, I Greenwald, and M Han
A gp330/megalin-related protein is required in the major epidermis of Caenorhabditis elegans for completion of molting
Development, January 2, 1999; 126(3): 597 - 606.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J. Maloof, J Whangbo, J. Harris, G. Jongeward, and C Kenyon
A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans
Development, January 1, 1999; 126(1): 37 - 49.
[Abstract] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Gu, S. Orita, and M. Han
Caenorhabditis elegans SUR-5, a Novel but Conserved Protein, Negatively Regulates LET-60 Ras Activity during Vulval Induction
Mol. Cell. Biol., August 1, 1998; 18(8): 4556 - 4564.
[Abstract] [Full Text]

Home page
 GeneticsHome page
D. Jacobs, G. J. Beitel, S. G. Clark, H. R. Horvitz, and K. Kornfeld
Gain-of-Function Mutations in the Caenorhabditis elegans lin-1 ETS Gene Identify a C-Terminal Regulatory Domain Phosphorylated by ERK MAP Kinase
Genetics, August 1, 1998; 149(4): 1809 - 1822.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
A. R. Cohen, D. F. Wood, S. M. Marfatia, Z. Walther, A. H. Chishti, and J. M. Anderson
Human CASK/LIN-2 Binds Syndecan-2 and Protein 4.1 and Localizes to the Basolateral Membrane of Epithelial Cells
J. Cell Biol., July 13, 1998; 142(1): 129 - 138.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
O. Hobert, T. D'Alberti, Y. Liu, and G. Ruvkun
Control of Neural Development and Function in a Thermoregulatory Network by the LIM Homeobox Gene lin-11
J. Neurosci., March 15, 1998; 18(6): 2084 - 2096.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L Nilsson, X Li, T Tiensuu, R Auty, I Greenwald, and S Tuck
Caenorhabditis elegans lin-25: cellular focus, protein expression and requirement for sur-2 during induction of vulval fates
Development, January 12, 1998; 125(23): 4809 - 4819.
[Abstract] [PDF]

Home page
 DevelopmentHome page
D Levitan and I Greenwald
Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans
Development, January 9, 1998; 125(18): 3599 - 3606.
[Abstract] [PDF]

Home page
 DevelopmentHome page
D. Eisenmann, J. Maloof, J. Simske, C Kenyon, and S. Kim
The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development
Development, January 9, 1998; 125(18): 3667 - 3680.
[Abstract] [PDF]

Home page
 DevelopmentHome page
D Levitan and I Greenwald
LIN-12 protein expression and localization during vulval development in C. elegans
Development, January 8, 1998; 125(16): 3101 - 3109.
[Abstract] [PDF]

Home page
 DevelopmentHome page
L. Jiang and P. Sternberg
Interactions of EGF, Wnt and HOM-C genes specify the P12 neuroectoblast fate in C. elegans
Development, January 6, 1998; 125(12): 2337 - 2347.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J. Maloof and C Kenyon
The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling
Development, January 1, 1998; 125(2): 181 - 190.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
A. Hajnal, C. W. Whitfield, and S. K. Kim
Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase
Genes & Dev., October 15, 1997; 11(20): 2715 - 2728.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C Wen, M. Metzstein, and I Greenwald
SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling
Development, January 12, 1997; 124(23): 4759 - 4767.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
H Sawa, L Lobel, and H R Horvitz
The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein.
Genes & Dev., September 1, 1996; 10(17): 2189 - 2197.
[Abstract] [PDF]

Home page
 DevelopmentHome page
C Guenther and G Garriga
Asymmetric distribution of the C. elegans HAM-1 protein in neuroblasts enables daughter cells to adopt distinct fates
Development, January 11, 1996; 122(11): 3509 - 3518.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J Harris, L Honigberg, N Robinson, and C Kenyon
Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position
Development, January 10, 1996; 122(10): 3117 - 3131.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M Labouesse, E Hartwieg, and H. Horvitz
The Caenorhabditis elegans LIN-26 protein is required to specify and/or maintain all non-neuronal ectodermal cell fates
Development, January 9, 1996; 122(9): 2579 - 2588.
[Abstract] [PDF]

Home page
 DevelopmentHome page
S Euling and V Ambros
Reversal of cell fate determination in Caenorhabditis elegans vulval development
Development, January 8, 1996; 122(8): 2507 - 2515.
[Abstract] [PDF]

Home page
 DevelopmentHome page
R Hoskins, A. Hajnal, S. Harp, and S. Kim
The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins
Development, January 1, 1996; 122(1): 97 - 111.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
G J Beitel, S Tuck, I Greenwald, and H R Horvitz
The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway.
Genes & Dev., December 15, 1995; 9(24): 3149 - 3162.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
N Singh and M Han
sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction.
Genes & Dev., September 15, 1995; 9(18): 2251 - 2265.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
K Kornfeld, K L Guan, and H R Horvitz
The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.
Genes & Dev., March 15, 1995; 9(6): 756 - 768.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
S Tuck and I Greenwald
lin-25, a gene required for vulval induction in Caenorhabditis elegans.
Genes & Dev., February 1, 1995; 9(3): 341 - 357.
[Abstract] [PDF]

Home page
 DevelopmentHome page
D. Church, K. Guan, and E. Lambie
Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans
Development, January 8, 1995; 121(8): 2525 - 2535.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M Koga and Y Ohshima
Mosaic analysis of the let-23 gene function in vulval induction of Caenorhabditis elegans
Development, January 8, 1995; 121(8): 2655 - 2666.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A. Newman, J. White, and P. Sternberg
The Caenorhabditis elegans lin-12 gene mediates induction of ventral uterine specialization by the anchor cell
Development, January 2, 1995; 121(2): 263 - 271.
[Abstract] [PDF]

Home page
 DevelopmentHome page
M. Labouesse, S. Sookhareea, and H. R. Horvitz
The Caenorhabditis elegans gene lin-26 is required to specify the fates of hypodermal cells and encodes a presumptive zinc-finger transcription factor
Development, September 1, 1994; 120(9): 2359 - 2368.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
Y Wu and M Han
Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.
Genes & Dev., January 15, 1994; 8(2): 147 - 159.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
M R Lackner, K Kornfeld, L M Miller, H R Horvitz, and S K Kim
A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.
Genes & Dev., January 15, 1994; 8(2): 160 - 173.
[Abstract] [PDF]

Home page
 DevelopmentHome page
H. Chamberlin and P. Sternberg
The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans
Development, January 10, 1994; 120(10): 2713 - 2721.
[Abstract] [PDF]

Home page
 DevelopmentHome page
G Seydoux and A Fire
Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans
Development, January 10, 1994; 120(10): 2823 - 2834.
[Abstract] [PDF]

Home page
 DevelopmentHome page
L Chen, M Krause, M Sepanski, and A Fire
The Caenorhabditis elegans MYOD homologue HLH-1 is essential for proper muscle function and complete morphogenesis
Development, January 6, 1994; 120(6): 1631 - 1641.
[Abstract] [PDF]

Home page
 DevelopmentHome page
J Austin and C Kenyon
Cell contact regulates neuroblast formation in the Caenorhabditis elegans lateral epidermis
Development, January 2, 1994; 120(2): 313 - 323.
[Abstract] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
P.W. Sternberg, C.H. Yoon, J. Lee, G.D. Jongeward, P.S. Kayne, W.S. Katz, G. Lesa, J. Liu, A. Golden, L.S. Huang, et al.
Molecular Genetics of Proto-oncogenes and Candidate Tumor Suppressors in Caenorhabditis elegans
Cold Spring Harb Symp Quant Biol, January 1, 1994; 59(0): 155 - 163.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
J Lee, G D Jongeward, and P W Sternberg
unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein.
Genes & Dev., January 1, 1994; 8(1): 60 - 73.
[Abstract] [PDF]

Home page
 DevelopmentHome page
S. Mitani, H. Du, D. H. Hall, M. Driscoll, and M. Chalfie
Combinatorial control of touch receptor neuron expression in Caenorhabditis elegans
Development, November 1, 1993; 119(3): 773 - 783.
[Abstract] [PDF]

Home page
 ScienceHome page
A Alfonso, K Grundahl, J. Duerr, H. Han, and J. Rand
The Caenorhabditis elegans unc-17 gene: a putative vesicular acetylcholine transporter
Science, July 30, 1993; 261(5121): 617 - 619.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
L M Miller, M E Gallegos, B A Morisseau, and S K Kim
lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development.
Genes & Dev., June 1, 1993; 7(6): 933 - 947.
[Abstract] [PDF]

Home page
 DevelopmentHome page
G Garriga, C Desai, and H. Horvitz
Cell interactions control the direction of outgrowth, branching and fasciculation of the HSN axons of Caenorhabditis elegans
Development, January 3, 1993; 117(3): 1071 - 1087.
[Abstract] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
P.W. Sternberg, R.J. Hill, G. Jongeward, L.S. Huang, and L. Carta
Intercellular Signaling during Caenorhabditis elegans Vulval Induction
Cold Spring Harb Symp Quant Biol, January 1, 1992; 57(0): 353 - 362.
[Abstract] [PDF]