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GENETIC STUDIES OF MEMBRANE EXCITABILITY IN DROSOPHILA: LETHAL INTERACTION BETWEEN TWO TEMPERATURE-SENSITIVE PARALYTIC MUTATIONS
Barry Ganetzky 1
1 Laboratory of Genetics, University of Wisconsin, Madison,
Wisconsin 53706
Two mutants of Drosophila melanogaster, para ts1 (1-53.9) and napts (2-56.2) both display similar temperature-sensitive paralysis associated with blockage in the conduction of nerve action potentials, suggesting that the two gene products have a similar function. This idea is supported by the observation that the double mutant is unconditionally lethal. Genetic analysis of this synergistic interaction has revealed the following: 1) it specifically involves the para and nap loci; (2) all para alleles interact with napts, but the strength of the interaction varies in an allele-dependent fashion; (3) lethality of the double mutant occurs during the first larval instar with parats1 but differs with other para alleles; (4) hypodosage of para + causes lethality in a napts background. These results together with previous electrophysiological, behavioral and pharmacological studies of these mutants suggest that both para and nap affect sodium channels and possibly encode different subunits.
Submitted on May 29, 1984Accepted on July 19, 1984
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