CONSERVED LINKAGE WITHIN A 4-cM REGION OF MOUSE CHROMOSOME 9 AND HUMAN CHROMOSOME 11

T. K. Antonucci ¹, O. H. Von Deimling ², B. B. Rosenblum ¹, L. C. Skow ³, and M. H. Meisler ¹

¹ Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, Michigan 48104
² Pathologisches Institut, Abteilung für Chemische Pathologie, Universität Freiburg, D-7800 Freiburg, i. Br. Bundesrepublik Deutschland
³ Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

A six-point cross was carried out to determine the gene order and distances among loci on mouse chromosome 9. Our results are consistent with the following arrangement: centromere – Lap-1 – (1.2 ± 0.8) – Es-17 – (3.0 ± 1.0) – Ups – (1.3 ± 0.7) – Alp-1 – (23.1 ± 3.4) – Mod-1 – (10.9 ± 2.6) – Acy-1 . This study provides the first estimate of the distances between Es-17, Ups and Alp-1. Exceptions to the preferred association of alleles of Es-17 and Ups have been found in three feral populations and one inbred strain. Evidence is presented for the homology of this chromosome region with the ESA4 – UPS – APO-AI region on the long arm of human chromosome 11.