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COINCIDENT GENE CONVERSION DURING MITOSIS IN SACCHAROMYCES
John E. Golin 1 and Michael S. Esposito 2
1 Institute of Molecular Biology, University of Oregon, Eugene,
Oregon 97403
2 Biology and Medicine Division, Lawrence Berkeley Laboratory,
University of California, Berkeley, California 94720
During mitosis, gene conversion events at the TRP5 locus on chromosome VII are coupled with conversion events at LEU1 , a locus 18 cM away, 1200 times more frequently than would be expected for two independent acts of recombination. Such coincident conversion events that occur over relatively long distances could be due to several mechanisms. We discuss these possibilities and describe an experiment that indicates that a portion of coincident events is due to extensive heteroduplexes. The phenomenon of coincident gene conversion is discussed in relation to our earlier evidence that spontaneous recombination between homologues occurs prereplicationally in mitosis.
Submitted on June 14, 1983Accepted on March 15, 1984
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