- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Macdonald, P. M.
- Articles by Mosig, G.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Macdonald, P. M.
- Articles by Mosig, G.
REGULATION OF A BACTERIOPHAGE T4 LATE GENE, soc, WHICH MAPS IN AN EARLY REGION
Paul M. Macdonald 1, Elizabeth Kutter 2, and Gisela Mosig 1
1 Department of Molecular Biology, Vanderbilt University, Nashville,
Tennessee 37235
2 The Evergreen State College, Olympia, Washington 98505
We have sequenced and analyzed the expression of an early region of the bacteriophage T4 genome that surprisingly contains a late gene, soc. soc is oriented in the same direction as early genes, like the T4 lysozyme gene. Northern hybridization of early and late T4 RNA, using cloned T4 restriction fragments as probes, identified two long early transcripts and a short late transcript, all containing the soc-coding sequence. Thus, soc is transcribed both early and late. It is, however, translated only late. The inhibition of soc translation from the long early transcripts can be explained by formation of a hairpin in the RNA that sequesters the soc ribosome-binding site. The transcript initiated at the late promoter cannot form this hairpin and is, therefore, translated.
Submitted on July 30, 1983Accepted on September 20, 1983
This article has been cited by other articles:
 |
|
 |
|
  E. A. Gibb and D. R. Edgell Multiple Controls Regulate the Expression of mobE, an HNH Homing Endonuclease Gene Embedded within a Ribonucleotide Reductase Gene of Phage Aeh1 J. Bacteriol., July 1, 2007; 189(13): 4648 - 4661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Bates, C. Toukoki, M. N. Neely, and Z. Eichenbaum Characterization of MtsR, a New Metal Regulator in Group A Streptococcus, Involved in Iron Acquisition and Virulence Infect. Immun., September 1, 2005; 73(9): 5743 - 5753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Opdyke, J. R. Scott, and C. P. Moran Jr. Expression of the Secondary Sigma Factor {sigma}X in Streptococcus pyogenes Is Restricted at Two Levels J. Bacteriol., August 1, 2003; 185(15): 4291 - 4297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Biswas and J. R. Scott Identification of rocA, a Positive Regulator of covR Expression in the Group A Streptococcus J. Bacteriol., May 15, 2003; 185(10): 3081 - 3090. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Miller, E. Kutter, G. Mosig, F. Arisaka, T. Kunisawa, and W. Ruger Bacteriophage T4 Genome Microbiol. Mol. Biol. Rev., March 1, 2003; 67(1): 86 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kai and T. Yonesaki Multiple Mechanisms for Degradation of Bacteriophage T4 soc mRNA Genetics, January 1, 2002; 160(1): 5 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ueno and T. Yonesaki Recognition and Specific Degradation of Bacteriophage T4 mRNAs Genetics, May 1, 2001; 158(1): 7 - 17. [Abstract] [Full Text]
|
|
|
|
|
|
T. P. Gary, N. E. Colowick, and G. Mosig A Species Barrier Between Bacteriophages T2 and T4: Exclusion, Join-Copy and Join-Cut-Copy Recombination and Mutagenesis in the dCTPase Genes Genetics, April 1, 1998; 148(4): 1461 - 1473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Adelman, G. Orsini, A. Kolb, L. Graziani, and E. N. Brody The Interaction between the AsiA Protein of Bacteriophage T4 and the sigma 70 Subunit of Escherichia coli RNA Polymerase J. Biol. Chem., October 24, 1997; 272(43): 27435 - 27443. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J M Gott, A Zeeh, D Bell-Pedersen, K Ehrenman, M Belfort, and D A Shub Genes within genes: independent expression of phage T4 intron open reading frames and the genes in which they reside. Genes & Dev., December 1, 1988; 2(12b): 1791 - 1799. [Abstract] [PDF]
|
|