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LINKAGE DISEQUILIBRIUM, SELECTION AND RECOMBINATION AT THREE LOCI
Alan Hastings 1
1 Department of Mathematics, University of California, Davis,
California 95616
Limits to the relationship among linkage disequilibrium, selection and recombination at equilibrium in three-locus, two-allele, deterministic, discrete generation models are determined using linear programming techniques. These results show that the commonly used measures of linkage disequilibrium are not appropriate for a multilocus setting. Additionally, interactions among three loci are important in reducing the strength of selection necessary to maintain a given level of disequilibrium, relative to a two-locus model.
Submitted on May 20, 1983Accepted on September 26, 1983
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