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LINKAGE DISEQUILIBRIUM, SELECTION AND RECOMBINATION AT THREE LOCI

Alan Hastings 1

1 Department of Mathematics, University of California, Davis, California 95616

Limits to the relationship among linkage disequilibrium, selection and recombination at equilibrium in three-locus, two-allele, deterministic, discrete generation models are determined using linear programming techniques. These results show that the commonly used measures of linkage disequilibrium are not appropriate for a multilocus setting. Additionally, interactions among three loci are important in reducing the strength of selection necessary to maintain a given level of disequilibrium, relative to a two-locus model.

Submitted on May 20, 1983
Accepted on September 26, 1983




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R. Gorelick and M. D. Laubichler
Decomposing Multilocus Linkage Disequilibrium
Genetics, March 1, 2004; 166(3): 1581 - 1583.
[Abstract] [Full Text] [PDF]


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Copyright © 1984 by the Genetics Society of America.