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MAXIMUM LIKELIHOOD ESTIMATION OF THE NUMBER OF NUCLEOTIDE SUBSTITUTIONS FROM RESTRICTION SITES DATA
Masatoshi Nei 1 and Fumio Tajima 1
1 Center for Demographic and Population Genetics, The University
of Texas at Houston, Houston, Texas 77025
A simple method of the maximum likelihood estimation of the number of nucleotide substitutions is presented for the case where restriction sites data from many different restriction enzymes are available. An iteration method, based on nucleotide counting, is also developed. This method is simpler than the maximum likelihood method but gives the same estimate. A formula for computing the variance of a maximum likelihood estimate is also presented.
Submitted on February 21, 1983Accepted on May 13, 1983
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