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ANALYSIS OF Y-LINKED MUTATIONS TO MALE STERILITY IN DROSOPHILA MELANOGASTER
James A. Kennison 1
1 Department of Biology, B-022, University of California, San
Diego, La Jolla, California 92093
The frequencies of newly induced male-sterilizing lesions on
both the X and Y chromosomes of Drosophila melanogaster
were determined after either 4000 r of 
-irradiation or adult
feeding of ethyl methanesulfonate. The Y chromosome is approximately
twice as sensitive as the X chromosome to newly induced male-sterilizing
lesions after -irradiation, but slightly less sensitive after ethyl
methanesulfonate treatment. A large proportion of the radiation-induced lesions
are associated with Y-autosome or X-autosome translocations,
with the Y chromosome recovered in translocations far in excess of
the frequency expected from metaphase lengths. Although translocations between
the X and Y chromosomes or between autosomes do not appear
to sterilize heterozygous males, interchanges between sex chromosomes and
autosomes often sterilize males carrying them in a dominant manner, suggesting
that the organization of the genome is critical for normal spermatogenesis.
Complementation tests between recessive Y-linked male-sterilizing
mutants do not reveal the existence of any additional fertility loci beyond
the six previously defined.
Accepted on September 30, 1982
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