Current Issue
- Canalization by Selection of de Novo Induced Mutations
Waddington elaborated the concepts of “canalization and assimilation” to explain how an apparently somatic, stress-induced variant...
- Powerful Genetic Association Analysis for Common or Rare Variants with High-Dimensional Structured Traits
Genetic association studies often collect a wide range of complex traits, including high-dimensional and structured omics measurements. The complex...
- A Lysine Desert Protects a Novel Domain in the Slx5-Slx8 SUMO Targeted Ub Ligase To Maintain Sumoylation Levels in Saccharomyces cerevisiae
Sumoylation is required to repair protein-linked DNA damage, but its presence can limit the use of alternative repair pathways. Through a suppressor...
- Rapid Evolution of Ovarian-Biased Genes in the Yellow Fever Mosquito (Aedes aegypti)
Males and females exhibit marked differences in phenotypes and gene expression, particularly in the gonads. Genes with male- or testisbiased expression..
- Toward Universal Forward Genetics: Using a Draft Genome Sequence of the Nematode Oscheius tipulae To Identify Mutations Affecting Vulva Development
Understanding evolution requires the comparison of more than a few model species, and exploration of the genotype/phenotype relationship is limited...
- Networks Underpinning Symbiosis Revealed Through Cross-Species eQTL Mapping
Interactions between species are pervasive among plants, animals, and microbes, and identifying the molecular signals involved is an active area of research..
- Shrinking Daughters: Rlm1-Dependent G1/S Checkpoint Maintains Saccharomyces cerevisiae Daughter Cell Size and Viability
How do cells ensure everything is set for cell division before they start the process? Piccirillo et al. demonstrate that a checkpoint in budding....
- Evolving Mistranslating tRNAs Through a Phenotypically Ambivalent Intermediate in Saccharomyces cerevisiae
It is increasingly apparent that the genetic code is not static and that organisms use variations in the genetic code for selective advantage. Berg...
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