Investigations

• Methods, Technology, and Resources

  • A New Tool for Inducible Gene Expression in Caenorhabditis elegans

    Gabriela C. Monsalve, Keith R. Yamamoto, Jordan D. Ward
  • Strategies for Efficient Genome Editing Using CRISPR-Cas9

    Behnom Farboud, Aaron F. Severson, Barbara J. Meyer
  • Robust CRISPR/Cas9-Mediated Tissue-Specific Mutagenesis Reveals Gene Redundancy and Perdurance in Drosophila

    Amy R. Poe, Bei Wang, Maria L. Sapar, Hui Ji, Kailyn Li, Tireniolu Onabajo, Rushaniya Fazliyeva, Mary Gibbs, Yue Qiu, Yuzhao Hu, Chun Han
  • Mapping Neurotransmitter Identity in the Whole-Mount Drosophila Brain Using Multiplex High-Throughput Fluorescence in Situ Hybridization

    Open Access

    Geoffrey W. Meissner, Aljoscha Nern, Robert H. Singer, Allan M. Wong, Oz Malkesman, Xi Long

• Statistical Genetics and Genomics

  • Joint Analysis of Multiple Interaction Parameters in Genetic Association Studies

    Jihye Kim, Andrey Ziyatdinov, Vincent Laville, Frank B. Hu, Eric Rimm, Peter Kraft, Hugues Aschard
  • R/qtl2: Software for Mapping Quantitative Trait Loci with High-Dimensional Data and Multiparent Populations

    Open Access

    Karl W. Broman, Daniel M. Gatti, Petr Simecek, Nicholas A. Furlotte, Pjotr Prins, Śaunak Sen, Brian S. Yandell, Gary A. Churchill

• Genome Integrity and Transmission

  • Rpd3L Contributes to the DNA Damage Sensitivity of Saccharomyces cerevisiae Checkpoint Mutants

    Open Access

    Belén Gómez-González, Harshil Patel, Anne Early, John F. X. Diffley
  • Uncoupling Sae2 Functions in Downregulation of Tel1 and Rad53 Signaling Activities

    Chiara Vittoria Colombo, Luca Menin, Riccardo Ranieri, Diego Bonetti, Michela Clerici, Maria Pia Longhese
  • Glucose Signaling Is Connected to Chromosome Segregation Through Protein Kinase A Phosphorylation of the Dam1 Kinetochore Subunit in Saccharomyces cerevisiae

    Sameer B. Shah, David Parmiter, Christian Constantine, Paul Elizalde, Michael Naldrett, Tatiana S. Karpova, John S. Choy

• Gene Expression

  • Cell Specificity of Human Regulatory Annotations and Their Genetic Effects on Gene Expression

    Arushi Varshney, Hadley VanRenterghem, Peter Orchard, Alan P. Boyle, Michael L. Stitzel, Duygu Ucar, Stephen C. J. Parker
  • Nucleosome Positioning by an Evolutionarily Conserved Chromatin Remodeler Prevents Aberrant DNA Methylation in Neurospora

    Andrew D. Klocko, Miki Uesaka, Tereza Ormsby, Michael R. Rountree, Elizabeth T. Wiles, Keyur K. Adhvaryu, Shinji Honda, Eric U. Selker

• Cellular Genetics

  • Mms21: A Putative SUMO E3 Ligase in Candida albicans That Negatively Regulates Invasiveness and Filamentation, and Is Required for the Genotoxic and Cellular Stress Response

    Amjad Islam, Faiza Tebbji, Jaideep Mallick, Hannah Regan, Vanessa Dumeaux, Raha Parvizi Omran, Malcolm Whiteway
  • Coupling of Human Rhodopsin to a Yeast Signaling Pathway Enables Characterization of Mutations Associated with Retinal Disease

    Benjamin M. Scott, Steven K. Chen, Nihar Bhattacharyya, Abdiwahab Y. Moalim, Sergey V. Plotnikov, Elise Heon, Sergio G. Peisajovich, Belinda S. W. Chang
  • A Novel Role for α-Importins and Akirin in Establishment of Meiotic Sister Chromatid Cohesion in Caenorhabditis elegans

    Richard Bowman, Nathan Balukof, Talitha Ford, Sarit Smolikove
  • Integration of Growth and Cell Size via the TOR Pathway and the Dot6 Transcription Factor in Candida albicans

    Julien Chaillot, Faiza Tebbji, Jaideep Mallick, Adnane Sellam
  • Two Antagonistic Hippo Signaling Circuits Set the Division Plane at the Medial Position in the Ciliate Tetrahymena

    Yu-Yang Jiang, Wolfgang Maier, Ralf Baumeister, Ewa Joachimiak, Zheng Ruan, Natarajan Kannan, Diamond Clarke, Panagiota Louka, Mayukh Guha, Joseph Frankel, Jacek Gaertig

• Developmental and Behavioral Genetics

  • Dynein Light Chain DLC-1 Facilitates the Function of the Germline Cell Fate Regulator GLD-1 in Caenorhabditis elegans

    Mary Ellenbecker, Emily Osterli, Xiaobo Wang, Nicholas J. Day, Ella Baumgarten, Benjamin Hickey, Ekaterina Voronina
  • The Caenorhabditis elegans SMOC-1 Protein Acts Cell Nonautonomously To Promote Bone Morphogenetic Protein Signaling

    Melisa S. DeGroot, Herong Shi, Alice Eastman, Alexandra N. McKillop, Jun Liu

• Population and Evolutionary Genetics

  • Fine-Grained Analysis of Spontaneous Mutation Spectrum and Frequency in Arabidopsis thaliana

    Open Access

    Mao-Lun Weng, Claude Becker, Julia Hildebrandt, Manuela Neumann, Matthew T. Rutter, Ruth G. Shaw, Detlef Weigel, Charles B. Fenster
  • Directional Selection Rather Than Functional Constraints Can Shape the G Matrix in Rapidly Adapting Asexuals

    Kevin Gomez, Jason Bertram, Joanna Masel

• Genetics of Complex Traits

  • The Genetic Basis of Mutation Rate Variation in Yeast

    Open Access

    Liangke Gou, Joshua S. Bloom, Leonid Kruglyak
  • Decoupling the Variances of Heterosis and Inbreeding Effects Is Evidenced in Yeast’s Life-History and Proteomic Traits

    Marianyela Petrizzelli, Dominique de Vienne, Christine Dillmann
  • Evidence for Weak Selective Constraint on Human Gene Expression

    Open Access

    Emily C. Glassberg, Ziyue Gao, Arbel Harpak, Xun Lan, Jonathan K. Pritchard

• Genome and Systems Biology

  • Mitochondrial Genome Variation Affects Multiple Respiration and Nonrespiration Phenotypes in Saccharomyces cerevisiae

    Sriram Vijayraghavan, Stanislav G. Kozmin, Pooja K. Strope, Daniel A. Skelly, Zhenguo Lin, John Kennell, Paul M. Magwene, Fred S. Dietrich, John H. McCusker