Current Issue
- Epistatic Networks Jointly Influence Phenotypes Related to Metabolic Disease and Gene Expression in Diversity Outbred Mice
In this study, Tyler et al. analyzed the complex genetic architecture of metabolic disease-related traits using the Diversity Outbred mouse population
- Adipocyte Metabolic Pathways Regulated by Diet Control the Female Germline Stem Cell Lineage in Drosophila melanogaster
Two papers in this issue demonstrate novel proteomic approaches that enhance genetic analysis. Matsuoka et al. investigated how diet-regulated........
- Genetic Dissection of Nutrition-Induced Plasticity in Insulin/Insulin-Like Growth Factor Signaling and Median Life Span in a Drosophila Multiparent Population
The insulin/insulin-like growth factor signaling (IIS) and target of rapamycin (TOR) pathways have long been thought to be involved in how organisms..
- Increased Power To Dissect Adaptive Traits in Global Sorghum Diversity Using a Nested Association Mapping Population
In crop species, adaptation to different agroclimatic regions creates useful variation but also leads to unwanted genetic correlations. Bouchet.......
- Alternative Polyadenylation Directs Tissue-Specific miRNA Targeting in Caenorhabditis elegans Somatic Tissues
Alternative polyadenylation (APA) is observed in virtually all metazoans and results in mRNA isoforms with different 3’ends. It is routinely...
- The Hippo Pathway Maintains the Equatorial Division Plane in the Ciliate Tetrahymena
The mechanisms governing organelle pattern formation in ciliates are still poorly understood. Jiang et al. investigate how the cell duplicates its....
- Genotypic Complexity of Fisher’s Geometric Model
In his celebrated model of adaptation, Fisher assumed a smooth phenotype fitness map with one optimum. This assumption is at odds with the rugged.....
- Proteomics Analysis Identifies Orthologs of Human Chitinase-Like Proteins as Inducers of Tube Morphogenesis Defects in Drosophila melanogaster
Two papers in this issue demonstrate novel proteomic approaches that enhance genetic analysis. Matsuoka et al. investigated how diet-regulated........
- A Physicist’s Quest in Biology: Max Delbrück and “Complementarity”
Max Delbruck was trained as a physicist but made his major contribution in biology and ultimately shared a Nobel Prize in Physiology/Medicine. He was.
- Structural Variation Shapes the Landscape of Recombination in Mouse
Meiotic recombination ensures the faithful segregation of chromosomes and influences patterns of genetic diversity. Morgan et al. used genotype data..
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