Current Issue
- Contrasting Determinants of Mutation Rates in Germline and Soma
A number of genomic features influence regional mutation rates in germline and soma. To examine if some factors behave differently in the two tissue...
- A Model for Epigenetic Inhibition via Transvection in the Mouse
Transvection—a phenomenon in which the allele on one chromosome genetically interacts with its paired allele on the homologous chromo-some.....
- Regulation of Lysosomal Function by the DAF-16 Forkhead Transcription Factor Couples Reproduction to Aging in Caenorhabditis elegans
Reproduction and aging are intertwined. While lifespan and reproductive strategies vary greatly among animals, the progeny production period generally...
- Remarkable Evolutionary Conservation of Antiobesity ADIPOSE/WDTC1 Homologs in Animals and Plants
Ducos et al. report that the farnesylated protein ASG2 is the Arabidopsis ortholog of human WDCT1, which controls fat accumulation. Both proteins harbor..
- MicroRNAs That Contribute to Coordinating the Immune Response in Drosophila melanogaster
Atilano et al. present a Drosophila post-infection survival screen that takes advantage of a library of miRNA mutant flies. Using genome wide microarray..
- Histone Acetylation, Not Stoichiometry, Regulates Linker Histone Binding in Saccharomyces cerevisiae
Linker histones play an important role in shaping chromatin structure, but the regulation of their interactions with chromatin is poorly understood...
- Mendelism: New Insights from Gregor Mendel’s Lectures in Brno
After dissolving misinterpretation and prejudice of the newspaper report of Mendel’s lectures, we found the lecture content can be recovered...
- Benchmarking Relatedness Inference Methods with Genome-Wide Data from Thousands of Relatives
Relatedness inference is an essential component of many genetic analyses and popular in consumer genetic testing. Ramstetter et al. evaluate twelve.....
- A Gene Implicated in Activation of Retinoic Acid Receptor Targets Is a Novel Renal Agenesis Gene in Humans
Renal agenesis is a devastating birth defect, and although genes encoding retinoic acid signaling components have been shown to be important for renal...
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